The MMTP and research on senolytic drugs

I’m a bit late for the party, but this is anyway something really worth mentioning.

If you have given a look to this page, you probably know about senescent cells. If you haven’t, I’ll tell you about them again. In a nutshell, senescent cells are cells no longer able to divide like healthy cells are supposed to do. All they do is stick around your body doing nothing useful, really, and while they’re at it, they interfere in other important processes. Pretty much like grumpy people who aren’t just content with sitting around twiddling their thumbs, but also bother other people and prevent them from carrying on their business. Jerks.

The consequences of having senescent cells sitting around are quite bad, and range from vascular diseases to higher chances to develop cancer to reduced immune capacity. It’s no coincidence that the elimination of senescent cells from the body is a keypoint of the SENS agenda.

Recent studies have shown that eliminating senescent cells from mice significantly improves their health in various ways (See, for example, this, this, this, and this). The way scientists have got mice rid of senescent cells is using senolytic drugs, and this is all great news, but the story is the same as with all other scientific discoveries: Not all aspects of the matter are 100% clear yet, and more research needs to be done. If things turned out well, senolytics could be used to increase human healthspan and lifespan, and get us rid of really bad age-related conditions.

In order to be able to carry on further research on the subject, Lifespan.io is presently running a crowdfunding campaign, namely the Major Mouse Testing Program (MMTP) which I urge you to support through donations, sharing the news on your social media, or both. Your youthful cells will be grateful—your senescent cells not so much, but they can stuff it.

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