Ending Aging in Portuguese

I would like to let you know that a crowdfunding campaign to translate Aubrey de Grey’s book Ending Aging in Portuguese is currently hosted on Catarse.me, Brasil’s largest crowdfunding platform.

If successful, this campaign will allow professional translators Nina T. Zanvettor and Nicolas Chernavsky to create both a paper and an e-book version of Ending Aging—or, in Portuguese, O Fim do Envelhecimento. The campaign will last until June 5th, 2018, so there’s plenty of time to collect the goal of R$ 28.000, a little less than 8.000 US dollars. On the campaign page, you’ll find a description of the project both in Portuguese and English; if you like, you can follow the campaign both on its own website and its Facebook page.

Importantly, this project has the endorsement of none else than Aubrey de Grey himself, as you can see in the video below.

If you speak Portuguese and would like to read Ending Aging in your own language, or you’d simply like to help spread the word in more languages, this crowdfunding campaign may interest you. I also invite you to spread the word on your social media, especially among your Portuguese-speaking friends. 🙂

Ending Aging in Italian

As you might know, I’m Italian. I’ve long left Italy, so I won’t be able to attend the event which I’ll shortly tell you about, but I would still like to give it some extra visibility.

Ending Aging, the book by Aubrey de Grey describing how medical science will be able to fully treat ageing in the foreseeable future, has been translated into Italian with the title La fine dell’invecchiamento (literally, ‘the end of ageing’). The book was published by D Editore—an independent Italian publishing house foucused on transhumanism and related topics—and will be presented on December 1st, 2016, at 18:00 at the bookstore Libreria Cultora, located in via Ughelli 39, 00179 Rome, Italy.

If you’re Italian or speak Italian, you might want to attend. If you know any Italian or Italian speaker, you could help the rejuvenation cause by letting them know of this event. Probably, the most effective way of spreading the word is sharing the relevant Facebook event.

I’d like to thank Emmanuele Pilia for the efforts he put into this project. If you wish, you may follow him on Twitter and/or D Editore, both on Twitter and Facebook.


News for MitoSENS?

A recently published article on ScienceDaily talks about research done on human fibroblast cells to put to test the so-called mitochondrial theory of ageing, according to which—in a nutshell— the abnormal mitochondrial function observed in aged humans is due to accumulation of mutations in mitochondrial DNA; this specific aspect of ageing could in principle be dealt with by implementing MitoSENS.

The news is, though, that according to this experiment it seems that mitochondrial DNA mutations don’t play that big of a role in the decline of mitochondrial function as thought; the researchers had at their disposal cells from young and elderly humans, and they observed that while the so-called mitochondrial respiration was expectedly lower in older cells than in young ones, the amoung of mutations wasn’t significantly different. Additionally, the researchers found out that by means of epigenetic regulation of the genes regulating glycine production in mitochondria, they were able to restore the respiratory function in the elderly cells.

This would seem to make MitoSENS useless, since it is all about addressing mutation-caused problems, but it is to be said that, from what I recall of my reading of Ending Aging, these mutations are quite rare (1% of your cells) even in old age, so perhaps it comes as no surprise that the researchers didn’t find any significant difference; I have no say as to whether or not they play a role in ageing. That’s all I can guess: I would recommend you have a look at Fight Aging’s article about it, or perhaps even the relevant paper published by the Japanese team led by professor Jun-Ichi Hayashi.

The bottom line, though, is the usual: we need to do more research. We need to establish beyond reasonable doubt the causes of ageing if we want to defeat it. No anti-ageing science is carved in stone yet, but every tiny piece of the puzzle that we add to the picture gets us closer to the moment when ageing will be finally under medical control.